COMPARE INVICIBLE WITH OTHER SCAR TREATMENTS
INVICIBLE IS AN EFFECTIVE, HYPOALLERGENIC SCAR TREATMENT CONTAINING:
- Dual Vitamin C Complex
- Dimethicone Silicone Gel
- ProBiosyn-4 Scar Treatment Complex (aloe vera, linoleic acid, oleic acid, licorice extract)
All InviCible’s ingredients are scientifically-proven to help scar healing. The table below shows how superior these ingredients are compared to those in other scar treatments:
One of skin’s main components is collagen. Scars heal through new collagen formation. Untreated skin produces unorganized, haphazard collagen. Vitamin C encourages the production of healthy, organized collagen1,2 which leads to faster and more cosmetic healing1. Vitamin C also decreases inflammation3,4,5,6 and lightens dark skin pigmentation3.
Silicone improves the appearance of both old and new scars 7,8,9. Silicone sheets are cumbersome and interfere with clothing and make-up. Silicone gel (Dimethicone) is as effective and is much easier to apply 7. Easy make-up application is an added benefit of InviCible.
1) Aloe Vera:
- accelerates wound healing10,11
- decreases inflammation10,11
- stimulates new skin growth through amino acids10,11
- promotes healthy healing in the deepest skin layers10,11
2) Two Essential Fatty Acids (EFAs): Linoleic Acid (Safflower Seed Oil) and Oleic Acid (Sunflower Seed Oil):
- regenerate lipid biolayer crucial for skin moisture12
- improve wound healing13
- improve scar elasticity12
- control production of prostaglandins, one of the skin’s main “building blocks.” Prevent disturbance in prostaglandin production which causes poor healing14-16
- lighten dark pigment (hyper-pigmentation)17
3) Licorice (Stearyl Glycyrrhetinate):
- strong anti-inflammatory18,19
- accelerates skin renewal20
- lightens dark pigment and brown spots including melasma20,21
- anti-acne effects (prevention and treatment)22
INGREDIENTS IN OTHER SCAR TREATMENTS
Several scientific studies in humans and animals have focused on the effect of topical onion extract on scars. Most showed no benefit 23-25. Onion extract performed no better than plain petroleum gel (or Vaseline®)26 for scar redness, itching, pain, burning, thickness and overall scar appearance.
VITAMIN E (Tocopherol)
Topical vitamin E is a powerful anti-oxidant and can even reverse the signs of sun damage. However, studies show that it has no benefit, or even worsens the appearance of scars in up to 90% of adults27,28. 33% of users developed a contact dermatitis to vitamin E (redness, itching and flaking)27,28. American dermatologists29 and Canadian pediatricians recommend completely avoiding scar products containing vitamin E30.
Independent studies have shown that topical steroids have no effect on scar thickness or cosmetic appearance28.
Most creams have a high water content, which encourages bacterial growth. Parabens and other preservatives prevent growth of bacteria. Unfortunately, parabens cause allergic reactions like dermatitis and eczema in 6% of users31. There is also evidence that they may be associated with cancer32-34 and possible hormonal imbalance34.
Popular parabens include Methylparaben, Ethylparaben, p-Propylparaben, Isobutylparaben, n-Butylparaben and Benzylparaben. InviCible does not contain water so it does not need preservatives.
Fragrances cause allergic reactions like dermatitis in up to 29% of users35.
InviCible is hypoallergenic – it does not contain preservatives, fragrances or vitamin E.
1. Fitzpatrick RE, Rostan EF. Double-blind, half-face study comparing topical vitamin C and vehicle for rejuvenation of photodamage. Dermatol Surg 2002;28:231-236.
2. Nusgens BV, Humbert P, Rougier A, et al. Topically applied vitamin C enhances the mRNA level of collagens I and III, their processing enzymes and tissue inhibitor of matrix metalloproteinase 1 in the human dermis. J Invest Dermatol 2001 Jun;116(6):853-859.
3. Farris PK. Topical vitamin C: a useful agent for treating photoaging and other dermatologic conditions. Dermatol Surg 2005;31:814-818.
4. Carcamo JM, Pedrazza A, Borquez-Ojeda O, et al. Vitamin C suppresses TNF alpha-induced NK kappa B activation by inhibiting I kappa B alpha phosphorylation. Biochemistry 2002;41:12995-300002.
5. Senftleben U, Karin M. The Ikk/NF-B pathway. Crit Care Med 2002;30S18-26.
6. Alster TS, West TB. Effect of topical vitamin C on postoperative carbon dioxide laser resurfacing erythema. Dermatol Surg 1998;24:331-334.
7. Mustoe TA. Evolution of silicone therapy and mechanism of action in scar management. Aesth Plast Surg 2008;32:82–92.
8. Chan KY, Lau CL, Adeeb SM, et al. A randomized, placebo-controlled, double-blind, pro-spective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound. Plast Reconstr Surg 2005;116:1013–1020.
9. Kuhn, M. A., Moffit, M. R., Smith, P. D., et al. Silicone sheeting decreases fibroblast activity and downregulates TGFbeta2 in hypertrophic scar model. Int. J Surg Invest 2: 467, 2001.
10. Davis RH, DiDonato JJ, Hartman GM, et al. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc 1994;84(2):77-81.
11. Davis RH, Rosenthal KY, Cesario LR, Rouw GA. Processed Aloe vera administered topically inhibits inflammation. J Am Podiatr Med Assoc 1989;79(8):395-7.
12. Jelenko C, Wheeler ML, Scott TH. Etyl linoleate: the water-holding lipid of skin. Effects on in vivo burn scar. J Trauma 1972;12;974-982.
13. Cardoso CR, Souza MA, Ferro EA, Favoreto S Jr, Pena JD. Influence of topical administration of n-3 and n-6 essential and n-9 nonessential fatty acids on the healing of cutaneous wounds. Wound Repair Regen. 2004 Mar-Apr;12(2):235-43.
14. Goldyne ME. Prostaglandins and cutaneous inflammation. J Invest Dermatol 1975;64:377-385.
15. Greaves MW. Prostaglandins and the epidermis. Br J Dermatol 1972;87:161-170.
16. Declair V. The usefulness of topical application of essential fatty acid (EFA) to prevent pressure ulcers. Ostomy Wound Manage 1997;43(5):48-54.
17. Ando H, Ryu A, Hashimoto A, et al. Linoleic acid and alpha-linolenic acid lightens ultraviolet-induced hyperpigmentation of the skin. Arch Dermatol Res. 1998 Jul;290(7):375-81.
18. Yokota T, Nishio H, Kubota Y, Mizoguchi M. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. 1998 Dec;11(6):355-61.
19. Tsukahara M, Nishino T, Furuhashi I, Inoue H, Sato T, Matsumoto H. Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts. Chem Pharm Bull (Tokyo). 2005 Sep;53(9):1103-10.
20. Amer M, Metwalli M. Topical liquiritin improves melasma. Int J Dermatol. 2000 Apr;39(4):299-301.
21. Fu B, Li H, Wang X, Lee FS, Cui S. Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase. J Agric Food Chem. 2005 Sep 21;53(19):7408-14.
22. Nam C, Kim S, Sim Y, Chang I. Anti-acne effects of Oriental herb extracts: a novel screening method to select anti-acne agents. Skin Pharmacol Appl Skin Physiol. 2003 Mar-Apr;16(2):84-90.
23. Jackson BA, Shelton AJ. Pilot study evaluating topical onion extract as treatment for postsurgical scars. Dermatol Surg 1999;25:267-269.
24. Saulis AS, Mogford JH, Mustoe TA. Effect of Mederma on hypertrophic scarring in the rabbit ear model. Plast Reconstruct Surg 2002;110:177-183.
25. Clarke LF, Baker B, Trahan C, et al. A prospective double-blinded study of Mederma skin care vs. placebo for post-traumatic scar reduction. Cosmetic Dermatol 1999;19-28.
26. Chung VQ, Kelly L, Marra D, et al. Onion extract gel versus petrolatum emollient on new surgical scars: a prospective double-blinded study. Dermatol Surg 2006;32:193-197.
27. Baumann LS, Spencer J. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-315.
28. Jenkins M, Alexander JW, MacMillan BG, et al. Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery. J Burn Care Rehabil 1986 Jul-Aug;7(4):309-12.
29. Zurada JM, Kriegel D, Davis IC. Topical treatments for hypertrophic scars. J Am Acad Dermatol 2006 Dec;55(6):1024-31.
30. Khoosal D, Goldman RD. Vitamin E for treating children’s scars. Does it help reduce scarring? Can Fam Physician 2006 Jul;52:855-6.
31. Lundov MD, Moesby L, Zachariae C, et al. Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergy. Contact Dermatitis 2009 Feb;60(2):70-8.
32. Darbre, PD, Aljarrah, A., Miller, WR., et al. Concentrations of parabens in human breast tumors. J Appl Toxicol. Jan 2004: (24): 5-13.
33. Harvey, PW, Darbre PD, Endocrine disruptors and human health: Could oestrogenic chemicals in body care cosmetics adversely affect breast cancer incidence in women? A review of evidence and call for further research. J Appl Toxicol. Jan 2004: (24): 167-176.
34. Darbre PD, Harvey PW. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. J Appl Toxicol. 2008 Jul;28(5):561-78.
35. Diepgen TL, Weisshaar E. Contact dermatitis: epidemiology and frequent sensitizers in cosmetics.
J Eur Acad Dermatol Venereol 2007 Sep;21(2):9-13.